Polynucleotide Treatments
Polynucleotides for anti-ageing and skin rejuvenation
Powerful skin regeneration, scientifically proven to regenerate the skin from within!
Polynucleotides are an injectable skin booster, primarily derived from salmon DNA, predominantly used to reduce wrinkles, stimulate cellular regeneration, collagen synthesis, and tissue repair.
These skin-boosting and regenerative injectables have become a popular choice for patients looking to combat the signs of ageing and/or address common skin concerns, such as:
- Lifting and tightening the skin
- Improving skin texture and smoothness
- Brightening the skin
- Increasing volume within the skin
- Minimising acne scars
- Minimising stretch marks
- Minimising/restoring hair loss
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Pricing: From £578 per session
What are polynucleotides and how do they work?
Polynucleotides are a component predominantly derived from salmon DNA, making them natural, compatible and biodegradable. Dr Bob Khanna explains that polynucleotides are “like food or medicine for cells, making them produce collagen and elastin and helping to improve the extracellular matrix” (that’s the structural support layer within our skin that keeps us looking youthful, containing those fibrous elements such as collagen, elastic etc).
Sometimes, Polynucleotides treatments can be referred to as Biostimulators or Biorevitalisers (depending on the manufacturer and composition), but they all contain the core anti-ageing ingredient; polynucleotides.
Polynucleotides are scientifically proven to:
- Stimulate and boost collagen and elastin production
- Durably and efficiently repair the skin (and hair) at a cellular level
- Hydrate the skin at a cellular level
- Improve tissue firmness and elasticity
- Have anti-inflammatory properties
- Promote cellular renewal
Dr Bob Khanna’s NuFace Protocols
Dr Khanna’s unique combination of Polynucleotides and Biofillers, for the face, neck and hands
In cases with more severe volume loss, this is addressed with our NuFace Protocol. This treatment combines both biofillers (dermal fillers) and polynucleotides into the same treatment, and is ideal for cases that require both volume restoration and skin rejuvenation/tightening at a cellular level.
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Pricing
NuFace | NuNeck | NuHands
- Per area: £650 – £995
NuFace Full
- 4 areas: £2950
- 8 areas: £4950
Polynucleotides treatment before and after
Polynucleotide treatment FAQs
What are polynucleotides made out of?
Traditional anti-wrinkle treatments (like Botox) typically last 3-4 months. Polynucleotide treatments, on the other hand, can last between 6-12 months, with ongoing improvements to skin quality long after the initial effects.
How much is polynucleotide treatment?
Polynucleotide treatment sessions with us start at £578. For NuFace, areas range from £650 - £950 or we offer full packages, with 4 areas at £2950 and 8 areas at £4950.
How long do polynucleotides take to work?
While most anti-ageing treatments take months to show improvements, you can see visible results from polynucleotide treatments within approximately 3 weeks, with full effects becoming more apparent over several months. The skin will gradually improve in texture, firmness and hydration.
When combined with hyaluronic acid (such as in our NuFace Protocol), the effects can be immediate!
How many sessions of polynucleotides do you need?
Usually 3 treatments, 4 weeks apart are required to achieve optimal results. A top up every 12 months is recommended to continue to enjoy the effects.
Are polynucleotides safe?
Yes, polynucleotides are considered very safe for facial aesthetic treatments. They are biocompatible molecules naturally found in the body and are carefully purified for cosmetic use. Clinical studies have shown they are well-tolerated, with minimal risk of allergic reactions or side effects. As with any injectable treatment, it’s important to have them administered by a qualified professional to ensure the highest safety standards.
What's the difference between polynucleotides and dermal fillers?
Unlike dermal fillers that simply plump the skin temporarily, polynucleotides regenerate skin at the cellular level. They boost hydration, collagen production, and skin elasticity.
Dr Khanna's NuFace Protocol combines polynucleotides with biofillers (an advanced dermal filler designed for improving skin quality alongside volume restoration).
What's best for me: Polynucleotides, Biostimulators or Exosomes?
When it comes to regenerative aesthetics, there are several advanced treatments available — but they work in different ways. Understanding the difference can help you choose the right solution for your skin or hair goals.
Exosomes
Tiny messengers produced by cells that carry proteins, lipids, and RNA.
Stimulate your body’s natural cell repair, regeneration, and collagen production.
Ideal for skin rejuvenation, anti-ageing, and hair restoration.
Key point: Encourages your cells to work smarter, restoring health and vitality from within.
Polynucleotides (PNs)
Long chains of nucleic acids (similar to DNA/RNA fragments) that support tissue repair.
Promote hydration, elasticity, and blood vessel formation.
Used for skin hydration, fine lines, and scar or stretch mark repair.
Key point: Provides “building blocks” for your skin, helping it repair and maintain hydration.
Biostimulators
Ingredients like poly-L-lactic acid or calcium hydroxylapatite.
Directly stimulate collagen production to restore volume, firmness, and elasticity.
Commonly used for wrinkles, folds, and skin laxity.
Key point: Works structurally by triggering collagen, rather than sending signals like exosomes.
The best option for you will be discussed within your consultation.
What's the difference between other polynucleotide treatments and Dr Khanna's NuFace Protocol?
Prof Khanna’s unique NuFace Protocol incorporates both biofillers and polynucleotides into the same treatment. It offers unparalleled results, both to replace volume loss and provide exceptional skin rejuvenation. The NuFace Protocol is ideal for the more severe cases of volume loss.
What are biofillers?
We use the latest biofillers from Pluryal®. Regular fillers are typically used to restore the volumes of the skin by filling its depressions; Biofillers, on the other hand, act way beyond regular fillers. Whilst they increase volume similar to normal dermal fillers, Biofillers also act as biostimulators, carefully healing the skin and boosting the production of new cell layers, ensuring maximum hydration at every cellular level and increasing skin’s smoothness, elasticity, and firmness.
More-natural looking results and migration prevention
Pluryal® Biofillers are manufactured using using 3 different types of hyaluronic acid, whose particles are much smaller than those used in standard products. This promotes the penetration and distribution of the dermal filler in the tissues, preventing migration and promoting more natural-looking results.
Do Polynucleotide treatments hurt?
At DrBK, we offer optional numbing cream before the treatment for those that are sensitive to needles. However most patients, particularly those who are used to 'botox', fillers or microneedling, may feel they do not require numbing at all.
Which DrBK clinic offers Polynucleotide treatments?
We offer polynucleotide and NuFace treatments at both of our locations in Reading (Queens Road) and London (Harley St). Book now.
Book your polynucleotide treatment at DrBK Reading & London
Experience the power of regenerative science with Polynucleotides at DrBK Clinic.
